Inclusion and exclusion criteria were determined prospectively, and the Oxford evidence classification system for diagnostic studies was used for evidence level. The search was performed for the period 1/2000-8/2008 within the data source of PubMed, DARE, and Cochrane databases.
MethodsĪ systematic search and review of studies involving mammography and breast ultrasound for screening of breast cancer was conducted. The purpose of this review is to estimate risks and benefits of supplemental breast ultrasound in women with negative mammographic screening with dense breast tissue. Mammographic breast density is a marker for increased breast cancer risk and is associated with a higher risk of interval breast cancer, i.e. Mammographic screening alone will miss a certain fraction of malignancies, as evidenced by retrospective reviews of mammograms following a subsequent screening.
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